Abstract: In this paper, a new methodology is presented to simulate deformation of soft objects by the reaction-diffusion analogy. The potential energy generated by an external force as a result of a deformation is propagated among mass points by the principle of reaction-diffusion. The novelty of the methodology is that the reaction-diffusion techniques are established to describe the potential energy of deformation and to extrapolate internal forces of a deformed object. An improved reaction-diffusion model is developed for the natural propagation of the energy generated by the external force. A method is presented to derive the internal forces from the potential energy distribution. The proposed methodology not only deals with large-range deformation, but also accommodates both isotropic and anisotropic materials by simply changing diffusion constants. Examples are presented to demonstrate the efficiency of the proposed methodology.