Abstract: In this paper, we propose a particle-based rheologic modeling framework for simulating thrombus formation in medical simulation applications. The effect of blood rheology has been simulated through a smoothed particle hydrodynamics (SPH) formulation of non-Newtonian flow. By modeling vessel wall and embolizing coil as virtual particles, a pure Lagrange particle formulation for fluid-structure interaction (FSI) is proposed for modeling the blood-vessel or blood-coil interaction. Having benefited from the elegant formulation of Lagrangian particle interaction; the simulation can be maintained at interactive frame-rates. Our proposed framework builds one of the common vascular complication sites, aneurysm, based on purely mess-less approach. Particles are distributed using angiography data or processed mesh-based data. A thrombus (clot) formation-dissolution model is integrated into this fluid-solid interaction framework. Results have demonstrated the feasibility of employing our proposed particle framework in simulating blood-vessel interaction in the clotting process which is essential to coil embolization simulations.