Abstract: Wrinkle is the most significant dynamic effects on cloth simulation. Although clothes with wrinkles make graphics more believable, many real time graphics systems make compromises on it because of time and space consuming. A region division based method is presented in this paper to add wrinkle effect to cloth while keeping the simulation speed fast enough to be real time. This method can simulate wrinkle effect without using additional cloth consists of different resolution mesh, which avoids the computation to build the connection between them and saves the space to store the additional cloth. With the concept of position based dynamics, a new method of region division is proposed. In this method, the entire cloth is treated as a connection of different regions. Cloth is divided into different regions according to the position of different joints. Vertex cover method is used to reduce the number of vertices to be taken into computation in each of these regions. Connections between different regions are built based on the position relationship between them. Practical experiment result shows that the method can simulate the wrinkle detail without using additional cloth consists of higher resolution mesh.