WaveMap: Interactively Discovering Features From Protein Flexibility Matrices Using Wavelet-based Visual Analytics
Scott Barlowe, Yujie Liu, Jing Yang, Dennis R. Livesay, Donald J. Jacobs, James Mottonen, Deeptak Verma
In Computer Graphics Forum, 30(3), June 2011.
Abstract: The knowledge gained from biology datasets can streamline and speed-up pharmaceutical development. However, computational models generate so much information regarding protein behavior that large-scale analysis by traditional methods is almost impossible. The volume of data produced makes the transition from data to knowledge difficult and hinders biomedical advances. In this work, we present a novel visual analytics approach named WaveMap for exploring data generated by a protein flexibility model. WaveMap integrates wavelet analysis, visualizations, and interactions to facilitate the browsing, feature identification, and comparison of protein attributes represented by two-dimensional plots. We have implemented a fully working prototype of WaveMap and illustrate its usefulness through expert evaluation and an example scenario.
@article{Barlowe:2011:WID,
author = {Scott Barlowe and Yujie Liu and Jing Yang and Dennis R. Livesay and Donald J. Jacobs and James Mottonen and Deeptak Verma},
title = {WaveMap: Interactively Discovering Features From Protein Flexibility Matrices Using Wavelet-based Visual Analytics},
journal = {Computer Graphics Forum},
volume = {30},
number = {3},
pages = {1001--1010},
month = jun,
year = {2011},
}
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