Visualizing Validation of Protein Surface Classifiers
A. Sarikaya, D. Albers, J. Mitchell, M. Gleicher
In Computer Graphics Forum, 33(3), 2014.
Abstract: Many bioinformatics applications construct classifiers that are validated in experiments that compare their results to known ground truth over a corpus. In this paper, we introduce an approach for exploring the results of such classifier validation experiments, focusing on classifiers for regions of molecular surfaces. We provide a tool that allows for examining classification performance patterns over a test corpus. The approach combines a summary view that provides information about an entire corpus of molecules with a detail view that visualizes classifier results directly on protein surfaces. Rather than displaying miniature 3D views of each molecule, the summary provides 2D glyphs of each protein surface arranged in a reorderable, small-multiples grid. Each summary is specifically designed to support visual aggregation to allow the viewer to both get a sense of aggregate properties as well as the details that form them. The detail view provides a 3D visualization of each protein surface coupled with interaction techniques designed to support key tasks, including spatial aggregation and automated camera touring. A prototype implementation of our approach is demonstrated on protein surface classifier experiments.
Keyword(s): Categories and Subject Descriptors (according to ACM CCS), J.3.1 [Computer Applications]: Life and Medical Sciences - Biology and Genetics
Article URL: http://dx.doi.org/10.1111/cgf.12373
BibTeX format:
@article{Sarikaya:2014:VVO,
  author = {A. Sarikaya and D. Albers and J. Mitchell and M. Gleicher},
  title = {Visualizing Validation of Protein Surface Classifiers},
  journal = {Computer Graphics Forum},
  volume = {33},
  number = {3},
  pages = {171--180},
  year = {2014},
}
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