Abstract: Examining and manipulating the large volumetric data attract great interest for various applications. For such purpose, we first extend the 2D moving least squares (MLS) technique into 3D, and propose a texture-guided deformation technique for creating visualization styles through interactive manipulations of volumetric models using 3D MLS. Our framework includes focus+context (F+C) visualization for simultaneously showing the entire model after magnification, and the cut-away or illustrative visualization for providing a better understanding of anatomical and biological structures. Both visualization styles are widely applied in the graphics areas. We present a mechanism for defining features using high-dimensional texture information, and design an interface for visualizing, selecting and extracting features/objects of interest. Methods of the interactive or automatic generation of 3D control points are proposed for the flexible and plausible deformation. We describe a GPU-based implementation to achieve real-time performance of the deformation techniques and the manipulation operators. Different from physical deformation models, our framework is goal-oriented and user-guided. We demonstrate the robustness and efficiency of our framework using various volumetric datasets.